Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 160, Issue 3, Pages 364-367Publisher
SPRINGER
DOI: 10.1007/s10517-016-3172-1
Keywords
oxidative stress; redox regulation; breast adenocarcinoma; apoptosis; tumor progress
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Funding
- Russian Humanitarian Research Foundation [15-36-01289]
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MCF-7 breast cancer cells and HBL-100 breast epithelial cells were cultured with N-ethylmaleimide, a blocker of SH groups. Changes in redox potential of the glutathione system, activities of glutathione reductase, glutathione peroxidase, and intensity of apoptotic cell death were evaluated. The results indicate that incubation with N-ethylmaleimide led to glutathione system imbalance, reduced tumor cell redox potential, and induced their programmed death, which seemed useful for prospective target therapy of tumor diseases.
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