Journal
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
Volume 33, Issue 3, Pages 427-429Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/jpem-2019-0388
Keywords
meta-analysis; precocious puberty; vitamin D
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Funding
- National Natural Science Foundation of China [81773412]
- Natural Science Foundation of Jilin Province [20190103095JH]
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The objective of this short communication was the relationship between vitamin D and precocious puberty (PP). In this study, a comprehensive search of multiple databases was performed to identify studies focused on the association between vitamin D deficiency and PP. Studies that compared serum vitamin D levels between patients with PP and controls were selected for the systematic meta-analysis. The main outcome was the mean difference in serum vitamin D levels between PP and controls. Vitamin D-deficient subjects were more likely to develop PP. Our findings suggest that PP may be linked to vitamin D deficiency. Thus, providing supplements of vitamin D to PP patients may improve their nutritional status and prevent diseases. But, the amount of vitamin D required is uncertain, so it is important to be careful when taking vitamin D supplements.
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