A simple, efficient and green approach for the synthesis of palladium nanoparticles using Oxytocin: Application for ligand free Suzuki reaction and total synthesis of aspongpyrazine A

A novel, green, eco-friendly and cost-effective biological route for the synthesis of palladium nanoparticles (PdNPs) from commercially available palladium chloride and easily isolable hormone Oxytocin as reducing agent is reported here. Characterization of PdNPs were done using various techniques, UV-visible spectroscopy, XRD, TEM and EDAX, characterization data confirmed the formation of Pd-0 from Pd2+. The size of synthesized PdNPs were 15-20 nm. The scope of Pd nanoparticles was studied for the C-C bond formation Suzuki reaction. The catalytic activity of PdNPs was excellent in short reaction time and reaction works in green solvent water as well as catalyst can be recycled. Simple and efficient approach for total synthesis of aspongpyrazine A of the recently isolated natural substance is described. (C) 2019 Published by Elsevier B.V.