Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 85, Issue 5, Pages 3902-3910Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b03006
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Funding
- National Natural Science Foundation of China [21762021]
- Science and Technology Project of Jiangxi Provincial Education Department [GJJ150297, GJJ150324]
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A convenient and straightforward strategy for the synthesis of 2,3-disubstituted and 2,3,5-trisubstituted furans via a base-promoted domino reaction of beta-keto compounds with vinyl dichlorides is described. This transition-metal-free approach proceeds under operationally simple reaction conditions featuring easily available starting materials, a broad substrate scope, and good functional group tolerance.
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