Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 85, Issue 5, Pages 2966-2975Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b02721
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Funding
- Swedish Research Council Formas [20151106]
- Swedish Research Council [2015-05360]
- Swedish Research Council [2015-05360] Funding Source: Swedish Research Council
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Selective direct ruthenium-catalyzed semihydrogenation of diaryl alkynes to the corresponding E-alkenes has been achieved using alcohols as the hydrogen source. The method employs a simple ruthenium catalyst, does not require external ligands, and affords the desired products in > 99% NMR yield in most cases (up to 93% isolated yield). Best results were obtained using benzyl alcohol as the hydrogen donor, although biorenewable alcohols such as furfuryl alcohol could also be applied. In addition, tandem semihydrogena-tionalkylation reactions were demonstrated, with potential applications in the synthesis of resveratrol derivatives.
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