Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 85, Issue 4, Pages 2520-2531Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b03228
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Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [2017R1A2B2004786, 2017R1D1A1A09000574, 2018M3A9C8021792, 2019R1A4A2001451]
- National Research Foundation of Korea [2018M3A9C8021792, 2017R1A2B2004786, 2017R1D1A1A09000574, 2019R1A4A2001451] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Ruthenium (II)-catalyzed C (sp(2))-H functionalization of N-aryl phthalazinones with a range of aldehydes and activated ketone is described. Initial formation of hydroxyalkylated phthalazinones and subsequent Mitsunobu cyclization provided facile access to biologically relevant indazolophthalazinones. The utility of this method is highlighted by synthetic transformations into a series of potentially bioactive scaffolds.
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