Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 85, Issue 7, Pages 4951-4962Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b03477
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- CSIR-India [HCP0008]
- DST-SERB
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Metal-free insertion of a methylene group was achieved for the construction of a new C(sp(2))-C(sp(3))-H-C(sp(2)) bond in order to prepare novel bis-heterocyclic scaffolds. The complete mechanistic investigations included experimental study and DFT calculations, and various symmetric and unsymmetric bispyrazoles as well as other pyrazole-based bis-heterocyclic molecules were prepared in moderate to high yields. Further modification of the bridged methylene group in the unsymmetric pyrazoles generated a chiral center to extend the scope of this method.
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