Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 85, Issue 3, Pages 1764-1768Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b03280
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Peptide coupling agents pose a special hazard because they are immune sensitizers. Here, we present a case study of anaphylaxis induced by three uronium coupling agents, HATU, HBTU, and HCTU, as a cautionary note for researchers who handle peptide coupling agents frequently. We also include recommendations for handling coupling agents more safely in the research laboratory.
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