4.7 Article

Ruthenium(II)-Catalyzed Construction of Isocoumarins via Dual C-H/C-C Activation of Sulfoxonium Ylides

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 85, Issue 2, Pages 1216-1223

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b02520

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Funding

  1. NSF of China [21672075]
  2. Instrumental Analysis Center of Huaqiao University

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A ruthenium(II)-catalyzed annulation between two molecules of sulfoxonium ylides is achieved, generating a variety of substituted isocoumarins in reasonable yields. This strategy features dual C-H/C-C activation in one pot and has a wide substrate scope and good functional group tolerance.

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