Journal
JOURNAL OF NEUROLOGY
Volume 267, Issue 5, Pages 1389-1400Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-019-09689-z
Keywords
Biomechanics; Frailty; Normal pressure hydrocephalus; Lumbar infusion test; Phase contrast magnetic resonance imaging; Neurodegenerative CNS changes
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Funding
- French Ministry of Health
- Groupement Interregional de Recherche Clinique et d'Innovation Sud-Ouest OutreMer Hospitalier (PHRCInterRegional 2010)
- Occitania Region (RPBIO 2015) [14054344]
- European Research Council under the European Union's Seventh Framework Program (FP7/2007-2013)/ERC grant [615102]
- European Research Council (ERC) [615102] Funding Source: European Research Council (ERC)
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Frailty is known to predict dementia. However, its link with neurodegenerative alterations of the central nervous system (CNS) is not well understood at present. We investigated the association between the biomechanical response of the CNS and frailty in older adults suspected of normal pressure hydrocephalus (NPH) presenting with markers of multiple co-existing pathologies. The biomechanical response of the CNS was characterized by the CNS elastance coefficient inferred from phase contrast magnetic resonance imaging and intracranial pressure monitoring during a lumbar infusion test. Frailty was assessed with an index of health deficit accumulation. We found a significant association between the CNS elastance coefficient and frailty, with an effect size comparable to that between frailty and age, the latter being the strongest known risk factor for frailty. Results were independent of CSF dynamics, showing that they are not specific to the NPH neuropathological condition. The CNS biomechanical characterization may help to understand how frailty is related to neurodegeneration and detect the shift from normal to pathological brain ageing.
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