Journal
JOURNAL OF NEUROINFLAMMATION
Volume 17, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12974-020-1701-3
Keywords
Sepsis-associated encephalopathy; Immune suppression; Vicious cycle; Therapeutic target
Categories
Funding
- National Natural Science Foundation of China [81730057, 81842025, 81801935]
- National Key Research and Development Program of China [2017YFC1103302]
- Military Medical Innovation Program of Chinese PLA [18CXZ026]
- Shenzhen San-ming Project [SZSM20162011]
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Sepsis-associated encephalopathy (SAE) is commonly complicated by septic conditions, and is responsible for increased mortality and poor outcomes in septic patients. Uncontrolled neuroinflammation and ischemic injury are major contributors to brain dysfunction, which arises from intractable immune malfunction and the collapse of neuroendocrine immune networks, such as the cholinergic anti-inflammatory pathway, hypothalamic-pituitary-adrenal axis, and sympathetic nervous system. Dysfunction in these neuromodulatory mechanisms compromised by SAE jeopardizes systemic immune responses, including those of neutrophils, macrophages/monocytes, dendritic cells, and T lymphocytes, which ultimately results in a vicious cycle between brain injury and a progressively aberrant immune response. Deep insight into the crosstalk between SAE and peripheral immunity is of great importance in extending the knowledge of the pathogenesis and development of sepsis-induced immunosuppression, as well as in exploring its effective remedies.
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