Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 339, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2019.577088
Keywords
Kynurenine pathway; Quinolinic acid; Indoleamine-2, 3-dioxygenase; Subacute sclerosing panencephalitis
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Funding
- Ministry of Health, Labor and Welfare (the Research Committee of Prion Disease and Slow Virus Infection) of Japan
- JSPS KAKENHI Grant [JP15K09654]
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Subacute sclerosing panencephalitis (SSPE) is a rare neurodegenerative disorder caused by a persistent infection with aberrant measles virus. Indoleamine-2, 3-dioxygenase (IDO) initiates the increased production of kynurenine pathway (KP) metabolites quinolinic acid (QUIN), which has an excitotoxic effect for neurons. We measured serum IDO activity and cerebrospinal fluid (CSF) levels of QUIN. The CSF QUIN levels were significantly higher in SSPE patients than in controls, and increased according as neurological disability in a patient studied. Elevation of CSF QUIN and progression of SSPE indicate a pathological role of KP metabolism in the inflammatory neurodestruction.
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