Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 340, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jneuroim.2020.577148
Keywords
Lymphocytes; Granzyme B; Runx3; Cerebrospinal fluid; Neuroinflammation; Methylprednisolone
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Funding
- Sao Paulo Research Foundation (FAPESP) [2015/22052-8, 2017/21363-5, 2019/06372-3]
- National Institute of Science and Technology in Neuroimmunomodulation (INCT-NIM) [465489/2014-1]
- CNPq Universal grant [406688/2016-8]
- FAEPEX-UNICAMP young researcher grant [2130/17]
- FAPESP young researcher fellowship [2012/01408-0]
- CNPq [311009/2014-0, 306248/2017-4]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (CAPES) [001]
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Our group is interested in the cytotoxic mechanism during autoimmune neuroinflammation. Unexpectedly, we come across a case that presents a massive enhancement of cytotoxic behavior in lymphocytes, either in peripheral blood and cerebrospinal fluid. Interestingly, this specific patient was refractory to Methylprednisolone treatment. Hypothetically, the cytotoxic activity could represent a novel and complementary effector mechanism to NMOSD pathogenesis. Nevertheless, further investigation is needed to evaluate the extension and the clinical relevance of our finds.
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