Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 127, Issue 2, Pages 213-230Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-019-02133-6
Keywords
Neurotoxicity; Aminochrome; Apoptosis; Autoxidation; Dopamine; Highly reactive oxygen species (hROS); 4-Hydroxynonenal; Mitochondria; Iron release; Necrosis; Oxidative damage; Parkinson's disease; Peroxynitrite; Reactive oxygen species (ROS)
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6-Hydroxydopamine (6-OHDA), which is a neurotoxin that selectively destroys catecholaminergic nerves in sympathetically innervated tissues, has been used to provide a model of Parkinson's disease in experimental animals. It is rapidly autoxidised to yield potentially toxic products and reactive oxygen species. Its ability to release Fe(II) from protein storage sites also results in the formation of hROS. This account will consider how this family of toxic products may contribute to the observed effects of 6-OHDA.
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