Journal
JOURNAL OF NEURAL ENGINEERING
Volume 17, Issue 2, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1741-2552/ab77f9
Keywords
drive implant; tetrode; chronic electrophysiology; microdrive
Categories
Funding
- MIT Research Support Committee-NEC corporation fund for research in computers and communications
- Simons Center for the Social Brain at MIT postdoctoral fellowship [R21-EY028 381]
- Center for Brains, Minds and Machines - NSF STC [CCF-1231 216]
- NIH Posdoctoral Ruth L Kirschstein National Research Service Award [1F32MH107 086-01, TR01-GM104 948, R01-MH092 638]
- Simons Foundation
- NIH [R01NS106 031, R21NS103 098]
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Tetrode arrays are a standard method for neuronal recordings in behaving animals, especially for chronic recordings of many neurons in freely-moving animals. Objective. We sought to simplify tetrode drive designs with the aim of enabling building and implanting a 16-tetrode drive in a single day. Approach. Our design makes use of recently developed technologies to reduce the complexity of the drive while maintaining a low weight. Main results. The design presents an improvement over existing implants in terms of robustness, weight, and ease of use. We describe two variants: a 16 tetrode implant weighing similar to 2 g for mice, bats, tree shrews and similar animals, and a 64 tetrode implant weighing similar to 16 g for rats and similar animals. These designs were co-developed and optimized alongside a new class of drive-mounted feature-rich amplifier boards with ultra-thin radio-frequency tethers, as described in an upcoming paper (Newman, Zhang et al in prep). Significance. This design significantly improves the data yield of chronic electrophysiology experiments.
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