Journal
JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 2, Pages 481-488Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b01147
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Funding
- JSPS KAKENHI [18K14346, 16H03285]
- Keio Gijuku Academic Development Funds
- Grants-in-Aid for Scientific Research [18K14346] Funding Source: KAKEN
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An antimalarial lipopeptide, ikoamide, was isolated from an Okeania sp. marine cyanobacterium. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral phase HPLC analyses, spectroscopic analyses, and derivatization reactions. Ikoamide showed strong antimalarial activity with an IC50 value of 0.14 mu M without cytotoxicity against human cancer cell lines at 10 mu M.
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