Journal
JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 2, Pages 216-222Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00470
Keywords
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Funding
- National Natural Sciences Foundation of China [31700303]
- Key Projects of Science and Technology Plan of Changsha [kq1801072]
- Science and Technology Innovation Platform and Talent Special Project of Hunan Province [2017TP2013]
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Palhinosides A-H (1-8), new flavone glucosidic truxinate esters, including beta-truxinate and mu-truxinate forms, were isolated from Palhinhaea cernua. Their structures were elucidated by extensive spectroscopic methods and chemical analyses. The flavone glucoside cyclodimers possess a unique cyclobutane ring in their carbon scaffolds. Compounds 2-7 represent three pairs of stereoisomers (2/3, 4/5, 6/7). The protective effects of 1-8 against the damage of HT-22 cells induced by L-glutamate were evaluated, and compounds 4 and 5 showed better neuroprotective effects than the positive control, Trolox.
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