Journal
JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 2, Pages 429-437Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00968
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Funding
- National Research Foundation (NRF) - Ministry of Science, Information and Communications Technology (ICT) and Future Planning, Korea [2018R1A4A1021703]
- BK21 Plus Program in 2018
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Isocadiolides A-H (1-8) and cadiolide N (9), new polybrominated aromatic compounds, were isolated from a Korean Synoicum sp. ascidian. On the basis of the results of extensive spectroscopic analyses, these compounds possessed tris-bromohydroxyphenyl moieties as a common structural motif, while their cores varied [cyclopentenedione (1-5), dihydrofuran (6 and 7), pyranone (8), and furanone (9)], reflecting different extents of rearrangement and oxidation. Several of these compounds exhibited weak antibacterial activities and moderate abilities to inhibit the microbial enzymes sortase A and isocitrate lyase.
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