Journal
JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 1, Pages 14-19Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00307
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Funding
- Thailand Research Fund (TRF)
- Office of the Higher Education Commission [MRG6180013]
- TRF [DBG6180030]
- Center of Excellence for Innovation in Chemistry (PERCH-CIC)
- Walailak University Fund [WU61201]
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Six new isopimarane diterpenes, marginaols A-F (1-6), along with eight known compounds (7-14), were isolated from the rhizomes of Kaempferia marginata. The structures and absolute configurations of 1-6 were established on the basis of spectroscopic methods and the experimental and calculated ECD data as well as comparison with the literature values. Most of the isolated compounds were tested for their nitric oxide (NO) inhibitory effects in lipopolysaccharide-activated RAW264.7 cells. Among them, marginaol B (2) was found to reduce NO levels in murine macrophage cells with an IC50 value of 28.1 +/- 1.7 mu M.
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