Journal
JOURNAL OF NATURAL PRODUCTS
Volume 83, Issue 1, Pages 20-25Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00414
Keywords
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Funding
- TWAS-CSIR
- Science and Engineering Research Board, Government of India [EMR/2015/002319]
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Three new isomeric corniculatolides (1, 2, and 3) with an unusual caffrane and isocorniculane framework, and five known metabolites were isolated from the chloroform extract of the stems of Xylocarpus granatum. The structures of the new metabolites were deduced as corniculatolide B (1), isocorniculatolide B (2), and corniculatolide C (3) by spectroscopic data analysis and a combination of chemical transformations and supported by single-crystal X-ray crystallographic data of 1 and 3. The isolated compounds were evaluated for their in vitro cytotoxicity and alpha-glucosidase (Saccharomyces cerevisiae) inhibitory potential. Compound 3 possessed alpha-glucosidase inhibitory activity with an IC50 value of 24.8 mu M, whereas these rare macrolides showed no effect on the mammalian cancer cell lines MIAPaCa-2, DU145, MCF-7, and HTC-116.
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