Silica-coated magnetic nanoparticles containing bis dicationic bridge for the synthesis of 1,2,4-triazolo pyrimidine/quinazolinone derivatives

In this work and for the first time, the preparation of bis-[(3-aminopropyl)triethoxysilane]dichloride immobilized on magnetic nano gamma-Fe2O3@SiO2 via the reaction of two molecules of 3-aminopropyl) triethoxysilane with 1,4-dichlorobutane followed by immobilization of the resulted di-cationic compound on silica-coated nano gamma-Fe2O3 is reported. After characterization using FT-IR, XRD, FE-SEM and TGA techniques, the prepared reagent was used for the efficient promotion of the synthesis of 1,2,4-triazolopyrimidine/quinazolinone derivatives with excellent rates and yields. The recovery and reusability of the catalyst were also studied for both of the reactions using an external magnet. (C) 2019 Elsevier B.V. All rights reserved.