Novel ruthenium doped TiO2/reduced graphene oxide hybrid as highly selective sensor for the determination of ambroxol

Clinical trials and quality control processes are always in need of an effective sensor for the trace level estimation of analyte. In present work, a sensor for ambroxol drug at electrochemically reduced graphene oxide (ErGO) and ruthenium doped TiO2 nanoparticles (RT) is proposed. RT/ErGO/CPE hybrid showed an increase in the peak current up to five-folds, signifying the potential of the sensor when compared with the nascent carbon paste electrode. The previously established calibration graph was used and LOD and LOQ in the range 0.1 mu M-0.6 mu M was 1.0 nM and 4.0 nM, respectively. The effect on peak current and potential was studied at different scan rates, pH and concentration. Repeatability of the sensor was confirmed by inter and intraday investigations of the ambroxol drug. The selectivity of the sensor was studied in the presence of common excipients. Further, the method was used successfully for the determination of ambroxol in pharmaceutical dosage forms as well as in human urine samples. (C) 2018 Elsevier B.V. All rights reserved.