Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 432, Issue 12, Pages 3565-3577Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2019.12.004
Keywords
Circadian clock; Proteomics; Post-translational modifications; Signaling
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Funding
- French National Research Agency under the Programme Investissement d 'Avenir (NExT (I-SITE)) [ANR-16-IDEX0007]
- Pays de la Loire regional council and Nantes Metropole
- Institute for Molecular Bioscience, The University of Queensland
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The circadian clock is an endogenous molecular timekeeping system that allows organisms to adjust their physiology and behavior to the time of day in an anticipatory fashion. In different organisms, the circadian clock coordinates physiology and metabolism through regulation of gene expression at the transcriptional and post-transcriptional levels. Until now, circadian gene expression studies have mostly focused primarily on transcriptomics approaches. This type of analyses revealed that many protein-encoding genes show circadian expression in a tissue-specific manner. During the last three decades, a long way has been traveled since the pioneering work on dinoflagellates, and new advances in mass spectrometry offered new perspectives in the characterization of the circadian dynamics of the proteome. Altogether, these efforts highlighted that rhythmic protein oscillation is driven equally by gene transcription, post-transcriptional and post-translational regulations. The determination of the role of the circadian clock in these three levels of regulation appears to be the next major challenge in the field. Crown Copyright (C) 2019 Published by Elsevier Ltd. All rights reserved.
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