Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 432, Issue 6, Pages 1769-1791Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2019.12.019
Keywords
programmed DNA breaks; DNA and RNA ADP-ribosylation; DNA demethylation; readers of ADP-ribosylated targets; regulation of transcription
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Funding
- French National Research Agency [ANR-18-CE44-0008]
- Electricit de de France
- Fondation ARC [PJA-20181208015]
- ABELA FRERES
- Agence Nationale de la Recherche (ANR) [ANR-18-CE44-0008] Funding Source: Agence Nationale de la Recherche (ANR)
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Covalent linkage of ADP-ribose units to proteins catalyzed by poly(ADP-ribose) polymerases (PARPs) plays important signaling functions in a plethora of cellular processes including DNA damage response, chromatin organization, and gene transcription. Poly- and mono-ADP-ribosylation of target macromolecules are often responsible both for the initiation and for coordination of these processes in mammalian cells. Currently, the number of cellular targets for ADP-ribosylation is rapidly expanding, and the molecular mechanisms underlying the broad substrate specificity of PARPs present enormous interest. In this review, the roles of PARP-mediated modifications of protein and nucleic acids, the readers of ADP-ribosylated structures, and the origin and function of programmed DNA strand breaks in PARP activation, transcription regulation, and DNA demethylation are discussed. (C) 2019 Elsevier Ltd. All rights reserved.
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