4.6 Article

Impact of a bioactive drug coating on the biocompatibility of magnesium alloys

Journal

JOURNAL OF MATERIALS SCIENCE
Volume 55, Issue 14, Pages 6051-6064

Publisher

SPRINGER
DOI: 10.1007/s10853-020-04365-4

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Funding

  1. NSFC [31700826]
  2. Chongqing Research Program of Basic Research and Frontier Technology [cstc2017jcyjAX0284]
  3. Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education [CQKLBST-2016-001]

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Magnesium alloys are promising materials for biodegradable vascular stents because of their good biocompatibility and physical properties. The poly-beta-hydroxybutyrate (PHB) coating with vascular endothelial growth factor and heparin was prepared on the surface of WE magnesium alloys by layer-by-layer self-assembly technique. In this study, the effects of magnesium alloys with bioactive drug coating on human umbilical vein endothelial cells (HUVECs) and blood compatibility were investigated. The results showed that magnesium alloys with bioactive drug coating could decrease platelet adhesion, platelet activation, hemolysis rate, fibrinogen adsorption and increase activated partial thromboplastin time, prothrombin time, dynamic clotting of magnesium alloys. In addition, magnesium alloys with bioactive drug coating did not alter cytoskeleton morphological features of HUVECs, promoted cell adhesion and cell growth, and inhibited cell apoptosis. Therefore, the magnesium alloys with bioactive drug coating can be considered as potential and degradable biomaterials for vascular stents.

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