Non-enzymatic Electroanalytical Sensing of Glucose Based on Nano Nickel-Coordination Polymers-Modified Glassy Carbon Electrode

Herein, we introduce a simple set of experiments to construct non-enzymatic glucose sensors. The modification procedure was initiated by electrodeposition of nickel-coordination polymers (denoted henceforth as Ni-CPs) at the surface of glassy carbon (GC) electrode decorated with carbonnanotubes (CNTs). The electrochemical sensing of glucose occurred through the electrocatalytic oxidation of glucose by the Ni-CP using the CNTs as a high-area catalyst support. During potential cycling, the continuous chemical regeneration of the Ni(II) in the reaction between Ni(III) and glucose expresses itself as a dramatic enhancement of the anodic current pertaining to the Ni(III)/Ni(II) redox couple. Effects of various factors such as scan rate and solution pH were evaluated. For the optimized sensor the detection limit was as low as 2.1 mu M glucose and with a linear response extending up to 400 mu M. The modified electrode showed good reproducibility, excellent anti-interference performance, and high stability during the electrochemical experiments. Moreover, the analytical function of the non-enzymatic sensors for quantitative detection of glucose was assessed in real samples with satisfying results.