Journal
JOURNAL OF INFECTION
Volume 80, Issue 3, Pages 310-319Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2019.11.024
Keywords
Antibody response; Clinical severity; Follow-up; Influenza A(H7N9)
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Funding
- National Science Fund for Distinguished Young Scholars [81525023]
- Program of Shanghai Academic/Technology Research Leader [18XD1400300]
- National Science and Technology Major Project of China [2017ZX10103009-0 05, 2018ZX10201001-010]
- National Key Plan [2016YFD0500302, 2017YFE0190800]
- Shenzhen Peacock Program [KQTD201203]
- AXA Research Fund
- Investissement d'Avenir program
- Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases program [ANR-10-LABX-62-IBEID]
- Models of Infectious Disease Agent Study of the National Institute of General Medical Sciences
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Objectives: The long-term dynamics of antibody responses in patients with influenza A(H7N9) virus infection are not well understood. Methods: We conducted a longitudinal serological follow-up study in patients who were hospitalized with A(H7N9) virus infection, during 2013-2018. A(H7N9) virus-specific antibody responses were assessed by hemagglutination inhibition (HAI) and neutralization (NT) assays. A random intercept model was used to fit a curve to HAI antibody responses over time. HAI antibody responses were compared by clinical severity. Results: Of 67 patients with A(H7N9) virus infection, HAI antibody titers reached 40 on average 11 days after illness onset and peaked at a titer of 290 after three months, and average titers of >= 80 and >= 40 were present until 11 months and 22 months respectively. HAI antibody responses were significantly higher in patients who experienced severe disease, including respiratory failure and acute respiratory distress syndrome, compared with patients who experienced less severe illness. Conclusions: Patients with A(H7N9) virus infection who survived severe disease mounted higher antibody responses that persisted for longer periods compared with those that experienced moderate disease. Studies of convalescent plasma treatment for A(H7N9) patients should consider collection of donor plasma from survivors of severe disease between 1 and 11 months after illness onset. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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