Journal
JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 57, Issue 2, Pages 830-841Publisher
WILEY
DOI: 10.1002/jhet.3829
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Funding
- Research Foundation of Mugla Sitki Kocman University [15/089]
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Twenty-four pyrazolo derivatives (1-4)(a-f) were synthesized and characterized by FTIR, H-1, and C-13 NMR (Nuclear Magnetic Resonance), and elemental analysis. The synthesized compounds were also investigated for their antioxidant and anticholinesterase activities. The compounds (3-4)(a-f) carrying morpholine ring were more active than the piperidinyl containing compounds (1-2)(a-f) in both activities. The compound 4f showed higher activity in both assays as compared with the others. Additionally, the anticholinesterase activity test provided higher values than the galantamine in the BChE assay. Therefore, compound 4f can be used as anticholinesterase agent and/or anticholinesterase assay standard.
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