Multicomponent reactions and supramolecular catalyst: A perfect synergy for eco-compatible synthesis of pyrido[2,3-d]pyrimidines in water

In this article, we have developed a straightforward, easy and exceedingly competent approach for the synthesis of 5-phenyl-5,6-dihydropyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-triones obtain in superior yields in a sole reaction pace with an air and humidity steady catalyst in water as a green solvent at 100 degrees C. The present procedure paves the approach for the synthesis of biologically fascinating molecular frameworks and has reward in conditions of little catalyst loading with palpable ambiguous and straightforward-to-do reaction circumstances with easy purification process. The used beta-cyclodextrin catalyst was recuperated and repeated several times devoid of noteworthy loss of catalytic activity, which is a crucial parameter of green synthesis.