Journal
JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 57, Issue 3, Pages 1379-1386Publisher
WILEY
DOI: 10.1002/jhet.3874
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Funding
- China Postdoctoral Science Foundation [2017M623070, 2017 M623070]
- National Natural Science Foundation of China [21462010, 31701821]
- Natural Science Foundation of the Department of Education of Guizhou Province [qian jiao he KY word [2016]091]
- Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University [2019GDGP0104]
- Guizhou University
- Ministry of Education [2019GDGP0104]
- Department of Education of Guizhou Province [[2016]091]
- Guizhou Science and Technology Fund Project [[2016]1006]
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A series of novel 1,2,4-triazol derivatives containing an amide moiety were synthesized and their antifungal activities were evaluated. The results indicated that some of the target compounds possessed good antifungal activities. Among them, compounds 6a, 6g, 6k, and 6m showed excellent antifungal activities against Botrytis cinerea, with an inhibition rate of 91.8%, 90.1%, 93.6%, and 91.2% at a concentration of 50 mu g/mL, which were superior to that of Pyrimethanil (82.8%). Meanwhile, compound 6b showed better antifungal activity against Phompsis sp, with an inhibition rate of 92.4%, in comparison with that of Pyrimethanil (85.1%).
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