Journal
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 35, Issue 9, Pages 1644-1651Publisher
WILEY
DOI: 10.1111/jgh.14973
Keywords
imaging and advanced technology; applied therapeutics; pancreas; pancreatic neoplasms; biology and therapy
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Funding
- Shanghai Committee of Science and Technology, China [16441906902]
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Background and Aim The European evidence-based guidelines (EEG) and American College of Gastroenterology Guidelines (ACGG) have been published to guide the management of pancreatic cystic lesions. We aim to evaluate the value of both guidelines in predicting advanced pancreatic cystic lesions (A-PCLs) with preoperatively imaging-suspected cystic mucinous pancreatic neoplasms (cMNs). Methods One hundred ninety-eight patients who underwent resections from 2013 to 2019 for suspected cMNs were retrospectively reviewed. Receiver operating characteristic curves were calculated and compared with measure diagnostic value. Results Sixty-two patients were diagnosed with A-PCLs pathologically. Cross-imaging modalities had comparable diagnostic accuracy to endoscopic ultrasound in type classification and A-PCLs prediction. Receiver operating characteristic curve comparison analyses showed that EEG absolute + MCN (EEG(AM)) and EEG relative + MCN (EEG(RM)) having at least one indications criteria were comparable to the ACGG (P = 0.21 and P = 0.45). For the criteria having at least two indications, ACGG was superior to EEG(AM) (P = 0.001) but comparable to EEG(RM)(P = 0.12). EEG(AM) >= 1 indication criteria was superior to >= 2 indications criteria (P = 0.02). EEG(RM) >= 1 indication criteria had comparable diagnostic performance with >= 2 indications criteria (P = 0.86). ACGG >= 2 indications criteria was superior to >= 1 indication criteria (P = 0.02). Conclusion On the basis of cross-imaging evaluations, both sets of guidelines were found to be helpful in identifying A-PCLs in suspected cMNs with comparable performance. EEG(AM) >= 1 indication criteria was superior to >= 2 indications criteria. ACGG >= 2 indications criteria was superior to >= 1 indication criteria.
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