Journal
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 35, Issue 6, Pages 1023-1031Publisher
WILEY
DOI: 10.1111/jgh.14949
Keywords
Akkermansia muciniphila; colon barrier; colorectal cancer; intestinal flora; vitamin D
Categories
Funding
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [18KJA350002]
- Natural Science Foundation of Jiangsu Province [BK20181470]
- Science and Technology Foundation of Xuzhou [KC18044]
- Natural Science Foundation of China [81403001]
- China Postdoctoral Science Foundation [2016T90510]
- Six talent peaks project in Jiangsu Province [YY-045]
- Qing Lan Project in Jiangsu Province
- Priority Academic Program Development of Jiangsu Higher EducationInstitutions [PAPD]
Ask authors/readers for more resources
Background To investigate the correlation between the level of circulating vitamin D and the development of colorectal cancer (CRC) and to clarify the effect and mechanism of vitamin D on the development of CRC. Methods Serum samples from 63 patients with CRC (CRC group) and 61 healthy volunteers (normal group) were collected. Azoxymethane + dextran sodium sulfate-induced CRC mouse model and dietary models with different doses of vitamin D were established to verify whether vitamin D supplementation could reverse the occurrence and development of CRC at the overall animal level. Intestinal barrier integrity and microbial defense response were evaluated by detection of intestinal flora and expression of related genes. Results In the clinical serum samples, compared with the normal group, the level of 25 (OH) D3 in the CRC group was relatively low (P < 0.01), which was consistent with the clinical situation in mice. Vitamin D deficiency aggravated the deterioration of enteritis and intestinal cancer in CRC mice, whereas the overall condition of CRC mice improved after vitamin D supplementation. Vitamin D has a significant regulatory effect on the homeostasis of the intestinal flora, particularly in the regulation of intestinal probiotics, Akkermansia muciniphila-mediated colon barrier integrity. Conclusions Vitamin D deficiency is closely related to the high incidence of CRC, and vitamin D supplementation can inhibit the occurrence and development of CRC. Vitamin D plays a role in the reversal of CRC mainly through the regulation of intestinal flora, especially the regulation of A. muciniphila-mediated colon barrier integrity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available