Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 217, Issue 4, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20191172
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Funding
- National Institutes of Health [R01AI026918, R01HL128903, K08AR075880, F30AI122702, T32GM007618]
- Howard Hughes Medical Institute
- Sandler Asthma Basic Research Center at UCSF
- Swiss National Science Foundation [P2EZP3_162266, P300PA_171591, P4P4PM_180832]
- Dermatology Foundation
- A.P. Giannini Foundation
- Robert Wood Johnson Foundation [74257]
- Swiss National Science Foundation (SNF) [P2EZP3_162266, P300PA_171591, P4P4PM_180832] Funding Source: Swiss National Science Foundation (SNF)
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Group 2 innate lymphoid cells (ILC2s) are tissue-resident cells prominent at barrier sites. Although precursors are found in blood, mature ILC2s can enter the circulation after small intestinal perturbation by migratory helminths and move to distant tissues to influence the local reparative response. Using fate-mapping and methods to bypass the lung or intestinal phases of Nippostrongylus brasiliensis infection, we show that blood ILC2s comprise heterogeneous populations derived from distinct tissues that are dependent on alarmins matched to the receptor profile of the specific tissue ILC2s. Activation of local ILC2s by tissue-specific alarmins induced their proliferation, lymph node migration, and blood dissemination, thus systemically distributing type 2 cytokines. These studies uncover a possible mechanism by which local innate responses transition to systemic type 2 responses by extrusion of activated sentinel ILC2s from tissue into the circulation.
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