Journal
JOURNAL OF CYSTIC FIBROSIS
Volume 19, Issue 5, Pages 700-703Publisher
ELSEVIER
DOI: 10.1016/j.jcf.2020.02.009
Keywords
Cystic Fibrosis; Cystic Fibrosis-related diabetes; Diabetes; Child; Glucose
Categories
Funding
- National Health and Medical Research Council of Australia
- Australasian Cystic Fibrosis Research Trust
- Regional Diabetes Support Scheme
- Sydney Children's Hospitals Foundation
- Australasian Paediatric Endocrine Care Grant from Pfizer
- Thoracic Society of Australia/New Zealand/Vertex Cystic Fibrosis Paediatric Clinical fellowship in 2016
- National Health and Medical Research Council postgraduate scholarship from 2018
- Australian Government Research Training Program Scholarship
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It is not yet known whether continuous glucose monitoring (CGM) abnormalities persist in young children with CF. We evaluated longitudinal CGM results for children with CF < 10 years of age. We performed 3-day CGM at baseline, 12 months, and 24 months on 11 CF children (1 female) initially aged mean (SD) 3.8 (2.5) years. CGM analysis included (i) mean sensor glucose (SG), (ii) standard deviation (SD) for SG, (iii) peak SG and (iv)% time spent above a threshold of 7.8 mmol/L. Only three (3/11, 27%) had normal CGM at all time-points. Nearly three quarters of the participants (8/11, 73%) spent more than 4.5 percent time > 7.8 mmol/L at one time-point, five of whom had an elevated percent time on a subsequent test. Young children with CF have glucose abnormalities detected by CGM that fluctuate over time. (C) 2020 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
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