Journal
JOURNAL OF CONTROLLED RELEASE
Volume 315, Issue -, Pages 76-84Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2019.09.013
Keywords
Lipid-DNAs; Adjuvants; Antigens; Cancer vaccines; Anti-metastasis
Funding
- National Research Foundation of Korea - Korean government (Ministry of Science and ICT
- MSIT) [NRF-2017M3D1A1039421, NRF-2017R1C1B1005804]
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Nucleic acids have been used as building blocks to assemble nanostructures by their sequence specific self-recognition properties, and resulting DNA architectures were applied as potential multifunctional drug carriers. Here, we report an amphiphilic lipid-DNA aggregate hybridized with pharmaceutically active DNA and peptide segments for cancer immunotherapy. The facile formulation of the CpG sequence and antigen peptide-bearing peptide nucleic acid representing immune-adjuvant and antigen, respectively, enabled the highly efficacious induction of antigen-specific immune activation. This immunotherapeutic formulation was evaluated in terms of multiple types of tumor growth and metastasis in vivo.
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