Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 563, Issue -, Pages 177-188Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2019.12.081
Keywords
Silver nanoparticles; Cysteamine; Nanoparticles dissolution; Etching; Physiological pH; Coordination complexes
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While silver nanoparticles (AgNP) are used in topical treatments and medical devices for humans, no smooth, safe remedy exists to remove them and avoid possible post-treatment uptake in the body. We show here that cysteamine hydrochloride (CYS center dot HCl), a simple FDA and EMA approved molecule, is able to dramatically accelerate the otherwise extremely slow oxidation of citrate-coated AgNP by O(2 )in a wide range of pH, including the physiological 7.4 value, obtaining the halving of AgNP concentration in t < 10 min. The dependence of oxidation kinetics on CYS concentration and pH is studied, finding faster processes on increasing CYS and basicity, despite the decrease of O-2 reduction potential. Complexation and electrochemical studies demonstrate that CYS adhesion to AgNP surface followed by formation of 1:2 Ag+:CYS complex is the driving force for the AgNP oxidation, this also giving a definitive explanation to the otherwise still unclear phenomenon of AgNP etching by thiols. The efficacy of CYS center dot HCl is verified also on AgNP coated with pectin and PEG-SH, and on AgNP immobilized on surfaces. (C) 2019 Elsevier Inc. All rights reserved.
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