Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 130, Issue 4, Pages 1611-1614Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI135905
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Funding
- NIMH NIH HHS [P30 MH062512] Funding Source: Medline
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Currently, the incidence of HIV infection exceeds the death rate from HIV, and as a result, the prevalence of individuals living with the infection continues to increase. A critical limitation preventing the development of curative strategies is the lack of knowledge regarding mechanisms that allow HIV-infected cells to persist in individuals during combination antiviral therapy (ART). In this issue of the JCI, Chaillon and coworkers assessed HIV-infected cells from various anatomic compartments obtained through a rapid autopsy program of individuals undergoing long-term ART. This study, made possible with strong community collaboration, provides new insights on the potential locations of reservoirs of HIV-infected cells that persist during therapy.
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