Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 174, Issue 11, Pages 1226-1243Publisher
WILEY
DOI: 10.1111/bph.13627
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Funding
- University Students Innovation Training Program of Shanghai Municipal Government [201610247134]
- Yangfan Project of Tongji University School of Medicine [2012YF05]
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Anthocyanins are a class of water-soluble flavonoids, which show a range of pharmacological effects, such as prevention of cardiovascular disease, obesity control and antitumour activity. Their potential antitumour effects are reported to be based on a wide variety of biological activities including antioxidant; anti-inflammation; anti-mutagenesis; induction of differentiation; inhibiting proliferation by modulating signal transduction pathways, inducing cell cycle arrest and stimulating apoptosis or autophagy of cancer cells; anti-invasion; anti-metastasis; reversing drug resistance of cancer cells and increasing their sensitivity to chemotherapy. In this review, the latest progress on the anticancer activities of anthocyanins and the underlying molecular mechanisms is summarized using data from basic research in vitro and in vivo, from clinical trials and taking into account theory and practice.
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