4.1 Article

Neurodevelopment of Nonmicrocephalic Children, After 18 Months of Life, Exposed Prenatally to Zika Virus

Journal

JOURNAL OF CHILD NEUROLOGY
Volume 35, Issue 4, Pages 278-282

Publisher

SAGE PUBLICATIONS INC
DOI: 10.1177/0883073819892128

Keywords

ZIKV; child development; physiotherapy; Bayley III

Funding

  1. INAGEMP-National Institute of Population Medical Genetics grant CNPq [465549/2014-4]
  2. INAGEMP-National Institute of Population Medical Genetics grant CAPES [88887.136366/2017-00]
  3. INAGEMP-National Institute of Population Medical Genetics grant FAPERGS [17/2551-0000521-0]
  4. Project: Zika virus: Uma abordagem translacional (CNPq grant) [440763/2016-9]
  5. Project: A Historia Natural do Zika Virus (Ministry of Health) [929698560001160-02]

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The aim of this work was to evaluate the cognitive, language, and motor development, after 18 months of life, of nonmicrocephalic children born to mothers with Zika virus infection during pregnancy. Participants were 37 children aged 18-29 months divided into 2 groups: 17 nonmicrocephalic children born to mothers who had Zika virus infection during pregnancy (ZIKVG) and 20 nonmicrocephalic children with no maternal history of infection matched by sex and age (control group). A semistructured interview and the Bayley Scale of Infant and Toddler Development (Bayley III) were used for their evaluation. One child in the ZIKVG presented low cognitive score, the same in the control group. There were no statistical differences between the 2 groups regarding cognitive, language, and motor development. This sample, although small, showed that a significant proportion of nonmicrocephalic children exposed prenatally to Zika virus had normal development. A longer follow-up is necessary to observe if no other adverse outcomes will appear in the future.

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