Journal
JOURNAL OF CHEMICAL PHYSICS
Volume 151, Issue 24, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.5128091
Keywords
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Funding
- German Research Foundation (DFG) [Bu-911-29-1]
- Russian Science Foundation [19-43-04116]
- state of Hesse
- Russian Science Foundation [19-43-04116] Funding Source: Russian Science Foundation
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In recent years, the hyperpolarization method Signal Amplification By Reversible Exchange (SABRE) has developed into a powerful technique to enhance Nuclear Magnetic Resonance (NMR) signals of organic substrates in solution (mostly via binding to the nitrogen lone pair of N-heterocyclic compounds) by several orders of magnitude. In order to establish the application and development of SABRE as a hyperpolarization method for medical imaging, the separation of the Ir-N-Heterocyclic Carbene (Ir-NHC) complex, which facilitates the hyperpolarization of the substrates in solution, is indispensable. Here, we report for the first time the use of novel Ir-NHC complexes with a polymer unit substitution in the backbone of N-Heterocyclic Carbenes (NHC) for SABRE hyperpolarization, which permits the removal of the complexes from solution after the hyperpolarization of a target substrate has been generated. Published under license by AIP Publishing.
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