Journal
JOURNAL OF CHEMICAL NEUROANATOMY
Volume 102, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jchemneu.2019.101706
Keywords
Cerebellar ataxia; 3-Acethylpyridine; Curcumin; Purkinje cells; Neuroprotection
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Funding
- Vice Chancellor of Research of the Shahid Beheshti University of Medical Sciences, Tehran, Iran [145]
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Background: Cerebellar ataxias comprise a group of terminal illnesses with ataxia as the main symptom. Curcumin as a yellow polyphenol was extracted from the rhizome ofCurcuma longa. Owing to its antioxidant, anti-inflammatory, anti-fibrotic and anti-tumor features, curcumin is considered as a potential therapeutic agent. Aim: In this study, we aim to investigate the neuroprotective effects of oral administration of curcumin on a rat model of cerebellar ataxia induced by neurotoxin 3-acetylpyridine. Methods: The animals were randomly separated into three groups (control, 3-acetylpyridine, and curcumin + 3-acetylpyridine). Next, motor performance and muscle electromyography activity were assessed. Then, in the molecular part of the study, the anti-apoptotic role of curcumin in cerebellar ataxia and its relationship to protection of Purkinje cells were investigated. Results: Curcumin treatment improved motor coordination and muscular activity, reduced cleaved caspase-3, and increased glutathione level in 3-AP-lesioned rats as well as total volumes of cerebellar granular and molecular layers. Conclusion: the present study implies that curcumin might have neuroprotective effects to counteract neurotoxicity of 3-AP-induced ataxia.
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