Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 235, Issue 7-8, Pages 5490-5500Publisher
WILEY
DOI: 10.1002/jcp.29551
Keywords
immunotherapy; intratumoral injection; tumor microenvironment
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Funding
- National Natural Science Foundation of China [81702271, 81972193]
- Scientific Research Foundation for Recruited Talents, West China Hospital of Stomatology Sichuan University [QDIF2019-1]
- China Postdoctoral Science Foundation [2019M650246]
- Department of Science and Technology of Sichuan Province [2019YJ0041]
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Tumor microenvironment is known to play important roles in tumor progression. Many therapies, targeting the tumor microenvironment, are designed and applied in the clinic. One of these approaches is in situ antitumor therapy. This way, bacteria, antibodies, plasmid DNA, viruses, and cells are intratumorally delivered into the tumor site as in-situ antitumor vaccine, which seeks to enhance immunogenicity and generate systemic T cell responses. In addition, this intratumoral therapy can alter the tumor microenvironment from immunosuppressive to immunostimulatory while limiting the risk of systemic exposure and associated toxicity. Contemporarily, promising preclinical results and some initial success in clinical trials have been obtained after intratumoral therapy.
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