Related references
Note: Only part of the references are listed.Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview
Suvankar Banerjee et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Gain of native conformation of Aurora A S155R mutant by small molecules
Garima Tanwar et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2019)
Design, synthesis, biological evaluation and molecular docking study of arylcarboxamido piperidine and piperazine-based hydroxamates as potential HDAC8 inhibitors with promising anticancer activity
Prakruti Trivedi et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)
How Does Chirality Determine the Selective Inhibition of Histone Deacetylase 6? A Lesson from Trichostatin A Enantiomers Based on Molecular Dynamics
Yang Zhang et al.
ACS CHEMICAL NEUROSCIENCE (2019)
Pathological role of a point mutation (T315I) in BCR-ABL1 proteinA computational insight
Vidya Rajendran et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2018)
Discovery of meta-sulfamoyl N-hydroxybenzamides as HDAC8 selective inhibitors
Chunlong Zhao et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
The structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity
Ahmed T. Negmeldin et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Diverse classes of HDAC8 inhibitors: in search of molecular fingerprints that regulate activity
Sk Abdul Amin et al.
FUTURE MEDICINAL CHEMISTRY (2018)
Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants
Martin Marek et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity
Tino Heimburg et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors
Taha Y. Taha et al.
ACS MEDICINAL CHEMISTRY LETTERS (2017)
Statistical Significance for Hierarchical Clustering
Patrick K. Kimes et al.
BIOMETRICS (2017)
Transcription regulation mechanism of the syntaxin 1A gene via protein kinase A
Takahiro Nakayama et al.
BIOCHEMICAL JOURNAL (2017)
Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases
Alokta Chakrabarti et al.
FUTURE MEDICINAL CHEMISTRY (2016)
Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis
Tino Heinnburg et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Histone Deacetylase 8: Characterization of Physiological Divalent Metal Catalysis
Michael R. Nechay et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2016)
Structural analysis of oncogenic mutation of isocitrate dehydrogenase 1
Vidya Rajendran
MOLECULAR BIOSYSTEMS (2016)
Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees
Ivica Letunic et al.
NUCLEIC ACIDS RESEARCH (2016)
Structural aspects of HDAC8 mechanism and dysfunction in Cornelia de Lange syndrome spectrum disorders
Matthew A. Deardorff et al.
PROTEIN SCIENCE (2016)
Impact of point mutation P29S in RAC1 on tumorigenesis
Vidya Rajendran et al.
TUMOR BIOLOGY (2016)
Accurate calculation of the absolute free energy of binding for drug molecules
Matteo Aldeghi et al.
CHEMICAL SCIENCE (2016)
Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders
Christophe Decroos et al.
BIOCHEMISTRY (2015)
Systematic Parameterization of Monovalent Ions Employing the Nonbonded Model
Pengfei Li et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)
Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents
Madhusoodanan Mottamal et al.
MOLECULES (2015)
HDAC8: a multifaceted target for therapeutic interventions
Alokta Chakrabarti et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2015)
Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation
I. Rettig et al.
CELL DEATH & DISEASE (2015)
Parameterization of Highly Charged Metal Ions Using the 12-6-4 LJ-Type Nonbonded Model in Explicit Water
Pengfei Li et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2015)
Drug resistance mechanism of PncA in Mycobacterium tuberculosis
Vidya Rajendran et al.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2014)
Taking into Account the Ion-Induced Dipole Interaction in the Nonbonded Model of Ions
Pengfei Li et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2014)
Lipid14: The Amber Lipid Force Field
Callum J. Dickson et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2014)
Histone Deacetylases: A Saga of Perturbed Acetylation Homeostasis in Cancer
Sabnam Parbin et al.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2014)
Identification of a Novel Aminotetralin Class of HDAC6 and HDAC8 Selective Inhibitors
Guozhi Tang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Inhibition and Mechanism of HDAC8 Revisited
Kai Chen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
Katrina J. Falkenberg et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Assessing the performance of MM/PBSA and MM/GBSA methods. 4. Accuracies of MM/PBSA and MM/GBSA methodologies evaluated by various simulation protocols using PDBbind data set
Huiyong Sun et al.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2014)
Discovery of the First Histone Deacetylase 6/8 Dual Inhibitors
David E. Olson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Assessing the Performance of MM/PBSA and MM/GBSA Methods. 3. The Impact of Force Fields and Ligand Charge Models
Lei Xu et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2013)
Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8
W. Yan et al.
ONCOGENE (2013)
Phase I study of the histone deacetylase inhibitor entinostat in combination with 13-cis retinoic acid in patients with solid tumours
R. Pili et al.
BRITISH JOURNAL OF CANCER (2012)
Results From a Pivotal, Open-Label, Phase II Study of Romidepsin in Relapsed or Refractory Peripheral T-Cell Lymphoma After Prior Systemic Therapy
Bertrand Coiffier et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia
Mark J. Bishton et al.
BLOOD (2011)
Assessing the Performance of the Molecular Mechanics/Poisson Boltzmann Surface Area and Molecular Mechanics/Generalized Born Surface Area Methods. II. The Accuracy of Ranking Poses Generated From Docking
Tingjun Hou et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2011)
An Acetylation Switch Modulates the Transcriptional Activity of Estrogen-Related Receptor α
Brian J. Wilson et al.
MOLECULAR ENDOCRINOLOGY (2010)
HDAC family: What are the cancer relevant targets?
Olaf Witt et al.
CANCER LETTERS (2009)
Docking of Hydroxamic Acids into HDAC1 and HDAC8: A Rationalization of Activity Trends and Selectivities
Gabriella Ortore et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2009)
The many roles of histone deacetylases in development and physiology: implications for disease and therapy
Michael Haberland et al.
NATURE REVIEWS GENETICS (2009)
Structural origin of selectivity in class II-selective histone deacetylase inhibitors
Guillermina Estiu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors
Keris KrennHrubec et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics
Paola Gallinari et al.
CELL RESEARCH (2007)
Automatic atom type and bond type perception in molecular mechanical calculations
Junmei Wang et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2006)
Histone deacetylase inhibitors as therapeutics for polyglutamine disorders
Rachel Butler et al.
NATURE REVIEWS NEUROSCIENCE (2006)
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
S Minucci et al.
NATURE REVIEWS CANCER (2006)
Toward selective histone deacetylase inhibitor design: Homology modeling, docking studies, and molecular dynamics simulations of human class I histone deacetylases
DF Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Development and testing of a general amber force field
JM Wang et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases
JR Somoza et al.
STRUCTURE (2004)
Histone deacetylases (HDACs): characterization of the classical HDAC family
AJM De Ruijter et al.
BIOCHEMICAL JOURNAL (2003)
The Protein Data Bank
HM Berman et al.
NUCLEIC ACIDS RESEARCH (2000)
Share Paper
