Journal
JOURNAL OF CELL BIOLOGY
Volume 219, Issue 1, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201910211
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Funding
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) within the Emmy Noether program, SPP2191
- Munich Cluster for Systems Neurology [EXC2145]
- Fritz Thyssen Foundation
- Paul Ehrlich Foundation
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The interior of nuclear pore complexes (NPCs) is densely filled with FG-nucleoporins that form a permeability barrier of a still-obscure nature. Celetti et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201907157) now reveal that FG-nucleoporins can undergo liquid-liquid phase separation and form liquid droplets that mimic permeability barrier properties of intact NPCs.
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