Spontaneous coronary artery dissection managed with a conservative or revascularization approach: a meta-analysis

Background The optimal treatment approach for spontaneous coronary artery dissection (SCAD) remains unclear. Objectives The study aims to compare in-hospital and long-term clinical outcomes of SCAD patients initially managed with medical therapy (conservative approach) versus percutaneous coronary intervention or coronary artery bypass grafting (revascularization approach) based on published data. Methods We identified relevant studies by performing a systematic search in the Ovid MEDLINE and Embase databases. Studies withNat least 10 that report in-hospital outcomes [death, myocardial infarction (MI) and revascularization] or long-term outcomes (death, MI, revascularization, SCAD recurrence, and heart failure) were included. Risk difference between conservative and revascularization approach was estimated with the inverse variance-weighted method in a fixed-effect or random-effect model. Results A total of 22 nonrandomized, observational studies were analyzed (N = 1435). Compared with the initial revascularization approach, the conservative approach was associated with a comparable risk of in-hospital outcomes [risk difference: death, -0.61% (95% confidence interval, -2.13-0.91%),P = 0.43; MI, -0.99% (-4.65-2.67%),P = 0.60; revascularization, -3.02% (-8.79-2.75%),P = 0.31] and long-term outcomes [death, -0.06% (-2.33-2.20%),P = 0.96; MI, 0.96% (-2.35-4.27%),P = 0.57; revascularization, -3.31% (-7.63-1.02%),P = 0.13; SCAD recurrence, 3.75% (-2.05-9.55%),P = 0.21; heart failure, -0.01% (-3.13-3.11%),P = 0.99]. There was no significant heterogeneity across these studies. Conclusion Pooled results suggest that SCAD patients initially managed with a conservative strategy may have similar in-hospital and long-term outcomes compared with those who received revascularization in the absence of ongoing ischemia or left main artery involvement. More data from prospective studies are warranted to validate these findings.