Journal
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
Volume 54, Issue 2, Pages 213-218Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.bjoms.2015.11.002
Keywords
Lymph node density; Oral squamous cell carcinoma; Lung metastasis
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Funding
- JSPS [24791821]
- Grants-in-Aid for Scientific Research [24791821] Funding Source: KAKEN
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The association between lymph node density and survival free of lung metastases in oral squamous cell carcinoma (SCC), has not been investigated so far to our knowledge. Lymph node density >= 0.07 has been reported by a multicentre international study to be a significant predictor of shorter survival in patients with oral SCC who have invaded nodes. We investigated whether a lymph node density of >= 0.07 correlates with shorter overall survival, survival free of distant metastases, and survival free of lung metastases, in patients with oral SCC and invaded lymph nodes. Thirty-five patients with histologically-confirmed invaded lymph nodes werestudied. Their density was calculated as the ratio of the number of invaded lymph nodes:total number of nodes. A density of >= 0.07 correlated significantly with shorter overall survival (p < 0.02), survival free of distant metastases (p < 0.01), and survival free of lung metastases (p < 0.01) on log rank testing. On testing by Cox's proportional hazards model of multivariate survival analysis with adjustment for the pathological stage (pstage IV/pstage III), and invaded surgical margins or extracapsular spread, or both, we found that lymph node density >= 0.07 was associated with significantly shorter survival (p < 0.02). We conclude that lymph node density predicts lung metastases in patients with oral SCC. (C) 2015 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
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