Inhibitory effects of aloin on TGFBIp-mediated septic responses

Aloin is the major anthraquinone glycoside obtained from the Aloe species. Transforming growth factor beta-induced protein (TGFBIp) is an extracellular matrix protein and released by primary human umbilical vein endothelial cells (HUVECs) and functions as a mediator of experimental sepsis. We hypothesized that aloin could reduce TGFBIp-mediated severe inflammatory responses in HUVECs and mice. Aloin effectively inhibited lipopolysaccharide (LPS)-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. Aloin suppressed TGFBIp-induced sepsis lethality and pulmonary injury. Therefore, aloin is a potential therapeutic agent for various severe vascular inflammatory diseases, with inhibition of the TGFBIp signaling pathway as the mechanism of action.

Automated summary

Aloin can reduce severe inflammatory responses mediated by the extracellular matrix protein TGFBIp, making it a potential therapeutic agent for various vascular inflammatory diseases.