Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 23, Issue 2, Pages 189-203Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2019.1711066
Keywords
Aloin; TGFBIp; sepsis; severe inflammation; HUVEC
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Aloin can reduce severe inflammatory responses mediated by the extracellular matrix protein TGFBIp, making it a potential therapeutic agent for various vascular inflammatory diseases.
Aloin is the major anthraquinone glycoside obtained from the Aloe species. Transforming growth factor beta-induced protein (TGFBIp) is an extracellular matrix protein and released by primary human umbilical vein endothelial cells (HUVECs) and functions as a mediator of experimental sepsis. We hypothesized that aloin could reduce TGFBIp-mediated severe inflammatory responses in HUVECs and mice. Aloin effectively inhibited lipopolysaccharide (LPS)-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. Aloin suppressed TGFBIp-induced sepsis lethality and pulmonary injury. Therefore, aloin is a potential therapeutic agent for various severe vascular inflammatory diseases, with inhibition of the TGFBIp signaling pathway as the mechanism of action.
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