Journal
JOURNAL OF APPLIED POLYMER SCIENCE
Volume 137, Issue 37, Pages -Publisher
WILEY
DOI: 10.1002/app.49088
Keywords
biomaterials; biomedical applications; functionalization of polymers; grafting; photopolymerization
Categories
Funding
- S-innovation Research Program for the Development of the biofunctional materials for realization of innovative medicine
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Owing to its excellent physicochemical properties, poly(ether ether ketone) (PEEK) has been used clinically for medical implants. However, its surface properties should be improved to further enhance its compatibility with a living organism and infection resistance. Here, we examined the surface construction via a combined process, that is, the self-initiated photoinduced graft polymerization of N,N-dimethylaminoethyl methacrylate (DMA) on PEEK substrate followed by polymer quaternization using various bromoalkanes (Q-PDMA-g-PEEK). Using a Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, the grafting and quaternarization of poly(DMA) (PDMA) on the PEEK substrate was confirmed. The degree of quaternizations was at least 60% even when the various bromoalkanes were reacted. The Q-PDMA-g-PEEK with 1-bromooctane (BrC8) (C-8-Q-PDMA-g-PEEK) substrate exhibited the highest zeta-potential of other Q-PDMA-g-PEEK substrates. However, no significant differences were observed in the degree of quaternization, thickness of the polymer layer, and hydrophilicity of all modified PEEK substrates. In addition, from antibacterial test with Escherichia coli, the C(8)Q-PDMA-g-PEEK substrate exhibited the highest antibacterial rate (80%) among Q-PDMA-g-PEEK substrates examined. Therefore, we concluded that the surface zeta-potential is the one an important parameter for manufacturing PEEK substrates with bactericidal properties.
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