Journal
JOURNAL OF APPLIED POLYMER SCIENCE
Volume 137, Issue 31, Pages -Publisher
WILEY
DOI: 10.1002/app.48923
Keywords
BSA; calcium alginate gel beads; diffusion behavior; gel shrinkage; hydrogel structure
Categories
Funding
- Medical Scientific Research Program of Dalian [1811113]
- Medical Research Program of Affiliated Zhongshan Hospital of Dalian University [DLDXZSYY-BK201707, DLDXZSYY-BK201807]
- Dalian University [20172QL014, 20172QL019]
- Liaoning BaiQianWan Talents Program [62]
Ask authors/readers for more resources
A simple and novel method using gel shrinkage to indirectly characterize the structure of calcium alginate gel (CAG) beads during the calcium alginate gelation process was presented in this study. The effect of preparation process parameters (gelling cations, bead diameter, and alginate M-w and concentration) on the structure of the CAG bead formation process was thoroughly investigated. It was found that (a) the concentration of the Na+ and Ca2+ ion in gel bath was found to be the determining factor in the gel structure formation process by regulating the dissociation of alginate and the complexation of the calcium; (b) Na+ acts as a competitor with calcium and a screen in the electrostatic repulsion; (c) the effect of beads size below 700 mu m on the structure of CAG beads can be neglected; and (d) the sodium alginate concentration has no significant effect on the gel formation process. Furthermore, the diffusion of bovine serum albumin (BSA) was controlled by the density of CAG bead. Consequently, a faster diffusion rate of BSA within the looser structure of beads can be observed. These results are keys to understanding the behavior and performance of beads in their utilization medium. (c) 2020 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48923.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available