Journal
JOURNAL OF ANTIBIOTICS
Volume 73, Issue 4, Pages 224-229Publisher
SPRINGERNATURE
DOI: 10.1038/s41429-019-0272-y
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Funding
- Japan Society for the Promotion of Science [16K01913]
- Grants-in-Aid for Scientific Research [16K01913] Funding Source: KAKEN
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A new antibacterial peptide named pentaminomycin C was isolated from an extract of Streptomyces cacaoi subsp. cacaoi NBRC 12748(T), along with a known peptide BE-18257A. Pentaminomycin C was determined to be a cyclic pentapeptide containing an unusual amino acid, N delta-hydroxyarginine (5-OHArg), by a combination of ESI-MS and NMR analyses. The structure of pentaminomycin C was determined to be cyclo(-l-Leu-d-Val-l-Trp-l-5-OHArg-d-Phe-). Pentaminomycin C exhibited antibacterial activities against Gram-positive bacteria including Micrococcus luteus, Bacillus subtilis, and Staphylococcus aureus. The biosynthetic gene cluster for pentaminomycin C and BE-18257A was identified from the genome sequence data of S. cacaoi subsp. cacaoi.
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